Article
Expression of CD70 (CD27L) Is Associated With Epithelioid and Sarcomatous Features in IDH-Wild-Type Glioblastoma.
Journal of neuropathology and experimental neurology - 1 Aug 2017
Pratt Drew, Pittaluga Stefania, Palisoc Maryknoll, Fetsch Patricia, Xi Liqiang, Raffeld Mark, Gilbert Mark R, Quezado Martha
Abstract excerpt
Glioblastoma is an aggressive, often recalcitrant disease. In the majority of cases, prognosis is dismal and current therapies only moderately prolong survival. Immunotherapy is increasingly being recognized as an effective treatment modality. CD70 is a transmembrane protein that shows restricted expression in tissue but has been described in various malignancies. Therapeutic targeting of CD70 has demonstrated...
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