Article

S-BEAM: A Semi-Supervised Ensemble Approach to Rank Potential Causal Variants and Their Target Genes in Microglia for Alzheimer’s Disease

2022-11-03

Abstract excerpt

Alzheimer’s disease (AD) is the leading cause of death among individuals over 65. Despite many AD genetic variants detected by large genome-wide association studies (GWAS), a limited number of causal genes have been confirmed. Conventional machine learning techniques integrate functional annotation data and GWAS signals to assign variants functional relevance probabilities. Yet, a large proportion of genetic varia...

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Literature Corpus work: 3d67f853-0850-59d6-8b62-44612004b9c7
DOI: 10.1101/2022.11.01.514771

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