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Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge

15 Apr 2022

Abstract excerpt

Humans have four IgG antibody subclasses that selectively or differentially engage immune effector molecules to protect against infections. Although IgG1 has been studied in detail and is the subclass of most approved antibody therapeutics, increasing evidence indicates that IgG3 is associated with enhanced protection against pathogens. Here, we report that IgG3 has superior capacity to mediate intracellular...

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Share to Cytomegalovirus and herpesvirus research
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PMID: 35486676
DOI: 10.1126/sciimmunol.abj1640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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