Article

PA200 differentially regulates the proteasome and inhibits migration of cancer cells

2024-12-20

Abstract excerpt

<h4>ABSTRACT</h4> Proteasome activator 200 (PA200) is upregulated in non-small cell lung cancer (NSCLC) and linked to poor prognosis. We previously demonstrated that the overexpression of PA200 in NSCLC is associated with immune evasion and reduced responsiveness to immune checkpoint inhibitors. The cell autonomous function of PA200 in cancer growth, however, is not solved. We here demonstrate that deletion of PA...

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Literature Corpus work: 3d27c84c-41e7-554a-b7f5-9e274f254827
DOI: 10.1101/2024.12.17.628836

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