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Article

Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancer.

Theranostics - 1 Jan 2023

Rubio Karla, Romero-Olmedo Addi J, Sarvari Pouya, Swaminathan Guruprasadh, Ranvir Vikas P, Rogel-Ayala Diana G, Cordero Julio, Günther Stefan, Mehta Aditi, Bassaly Birgit, Braubach Peter, Wygrecka Malgorzata, Gattenlöhner Stefan, Tresch Achim, Braun Thomas, Dobreva Gergana, Rivera Miguel N, Singh Indrabahadur, Graumann Johannes, Barreto Guillermo

Abstract excerpt

Background: Small cell lung cancer (SCLC) is an extremely aggressive cancer type with a patient median survival of 6-12 months. Epidermal growth factor (EGF) signaling plays an important role in triggering SCLC. In addition, growth factor-dependent signals and alpha-, beta-integrin (ITGA, ITGB) heterodimer receptors functionally cooperate and integrate their signaling pathways. However, the precise role of...

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ErbB Receptors
Extracellular vesicles in disease
Integrins
Lung Cancer Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA modifications and cancer

Small Cell Lung Carcinoma

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Identifiers

PMID: 37215577
DOI: 10.7150/thno.79493
PMCID: PMC10196829

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