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Article

TGF-beta and retinoic acid: regulators of growth and modifiers of differentiation in human epidermal cells.

1 Oct 1990

Abstract excerpt

In the epidermis of skin, a fine balance exists between proliferating progenitor cells and terminally differentiating cells. We examined the effects of TGF-beta s and retinoic acid (RA) on controlling this balance in normal and malignant human epidermal keratinocytes cultured under conditions where most morphological and biochemical features of epidermis in vivo are retained. Our results revealed marked and...

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PMID: 1708287
DOI: 10.1091/mbc.1.11.791

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