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Article

Influence of V54M mutation in giant muscle protein titin: a computational screening and molecular dynamics approach.

Journal of biomolecular structure & dynamics - 1 Apr 2017

Thirumal Kumar D, George Priya Doss C, Sneha P, Tayubi Iftikhar Aslam, Siva R, Chakraborty Chiranjib, Magesh R

Abstract excerpt

Recent genetic studies have revealed the impact of mutations in associated genes for cardiac sarcomere components leading to dilated cardiomyopathy (DCM). The cardiac sarcomere is composed of thick and thin filaments and a giant muscle protein known as titin or connectin. Titin interacts with T-cap/telethonin in the Z-line region and plays a vital role in regulating sarcomere assembly. Initially, we screened all...

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Identifiers

PMID: 27125723
DOI: 10.1080/07391102.2016.1166456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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