Article
Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma
2021-06-02
Abstract excerpt
Males exhibit higher incidence and worse prognosis for the majority of cancers, including glioblastoma (GBM). Disparate survival may be related to sex-biased responses to treatment, including radiation. Using a mouse model of GBM, we show that female cells are more sensitive to radiation, and that senescence represents a major component of the radiation therapeutic response in both sexes. Correlation analyses reve...
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Identifiers and source
- Literature Corpus work
- 3cd554d3-688d-5c8f-8f7a-15cc13585b45
- DOI
- 10.1101/2021.06.02.446756