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Article

Cooperative p16 and p21 action protects female astrocytes from transformation

20 Feb 2018

Abstract excerpt

Mechanisms underlying sex differences in cancer incidence are not defined but likely involve dimorphism (s) in tumor suppressor function at the cellular and organismal levels. As an example, sexual dimorphism in retinoblastoma protein (Rb) activity was shown to block transformation of female, but not male, murine astrocytes in which neurofibromin and p53 function was abrogated (GBM astrocytes). Correlated sex...

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PMID: 29458417
DOI: 10.1186/s40478-018-0513-5

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