Article

H3K27 trimethylation maintains baseline network excitability in epilepsy

2026-07-28

Abstract excerpt

<h4>ABSTRACT</h4> The processes by which epileptic insults precipitate the molecular, cellular, and network alterations in the brain that lead to epilepsy are poorly understood. We previously discovered that after status epilepticus (SE – an epilepsy inducing severe bout of seizures) the H3K27 methylase Enhancer of Zeste Homolog 2 (EZH2) is robustly induced and drives repression of genes. Both systemic pharmacol...

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Literature Corpus work: 3c86a1a9-55d8-5748-b52c-c12b18842d4b
DOI: 10.64898/2026.07.24.740616

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