Article

Selective hippocampal subfield atrophy mediates cognitive decline in Cushing’s Disease.

2025-07-22

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Cushing’s disease (CD) provides insight into how prolonged high cortisol exposure affects brain structure. While CD patients show cognitive and emotional symptoms linked to hippocampal function, detailed analysis of hippocampal subfield changes and their correlations with peripheral blood gene expression profiles remains limited. <bold>Methods</bold> The study in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3c78f901-c01f-5947-ace2-1a5dc2279ae9
DOI: 10.21203/rs.3.rs-7058713/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Selective hippocampal subfield atrophy mediates cognitive decline in Cushing’s Disease.DOI 10.21203/rs.3.rs-7058713/v1Read

Comparison of volumetric brain analysis in subjects with rheumatoid arthritis and ulcerative colitisSemantic proximity Read

Sulfiredoxin-1 blood mRNA expression levels negatively correlate with hippocampal atrophy and cognitive declineSemantic proximity Read

FreeSurfer based segmentation of hippocampal subfields: a review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative effortsSemantic proximity Read

Common genetic variants in the glucocorticoid receptor and the 11β-hydroxysteroid dehydrogenase type 1 genes influence long-term cognitive impairments in patients with Cushing's syndrome in remission.Semantic proximity Read

Mapping Pathways to Neuronal Atrophy in Healthy, Mid-aged Adults: From Chronic Stress to Systemic Inflammation to Neurodegeneration?Semantic proximity Read

Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans.Semantic proximity Read

The CACNA1C risk allele rs1006737 is associated with age-related prefrontal cortical thinning in bipolar I disorder.Semantic proximity Read

Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with ageSemantic proximity Read

Hippocampal Volume Changes in Patients with Mood Disorders: A Systematic Review of MRI StudiesSemantic proximity Read

Frontal cortical thinning and disease burden–related plasticity in episodic cluster headache: a whole-brain cortical and subcortical morphometry studySemantic proximity Read

Longitudinal development of hippocampal subregions from childhood to adulthoodSemantic proximity Read

Reduced DNA methylation of FKBP5 in Cushing's syndrome.Semantic proximity Read