The CACNA1C risk allele rs1006737 is associated with age-related prefrontal cortical thinning in bipolar I disorder.

doi:10.1038/tp.2017.57

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Article

The CACNA1C risk allele rs1006737 is associated with age-related prefrontal cortical thinning in bipolar I disorder.

Translational psychiatry - 11 Apr 2017

Soeiro-de-Souza M G, Lafer B, Moreno R A, Nery F G, Chile T, Chaim K, da Costa Leite C, Machado-Vieira R, Otaduy M C G, Vallada H

Abstract excerpt

Calcium channels control the inflow of calcium ions into cells and are involved in diverse cellular functions. The CACNA1C gene polymorphism rs1006737 A allele has been strongly associated with increased risk for bipolar disorder (BD) and with modulation of brain morphology. The medial prefrontal cortex (mPFC) has been widely associated with mood regulation in BD, but the role of this CACNA1C polymorphism in mPFC...

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PMID: 28398341
DOI: 10.1038/tp.2017.57
PMCID: PMC5416698

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