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Article

The Role of Loss-of-Function KCNH2 Variants in Cardiac Arrhythmias, Seizures and the Risk of Sudden Unexpected Death in Epilepsy.

Journal of neurochemistry - 1 Apr 2026

Lee Hian M, Gan Xue N, Aung Khaing Phyu, Forster Ian C, Reid Christopher A, Soh Ming S

Abstract excerpt

Sudden Unexpected Death in Epilepsy (SUDEP) is the leading cause of mortality in patients in epilepsy, yet its underlying mechanisms are poorly understood. Emerging evidence suggests a significant role for genetic factors that influence cardiac function in SUDEP risk, particularly loss-of-function variants in KCNH2, which encodes the Kv11.1 potassium channel. Kv11.1 channels are expressed in both cardiac and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41981942
DOI: 10.1111/jnc.70441
PMCID: PMC13080245

Genes

KCNH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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