Article

New MiniPromoter Ple389 (ADORA2A) Drives Selective Expression in Medium Spiny Neurons in Mice and Non-human Primates

2024-11-04

Abstract excerpt

<title>Abstract</title> <p>Compact cell type-specific promoters are important tools for basic and preclinical research and clinical delivery of gene therapy. In this work, we designed novel MiniPromoters to target D1 and D2 type dopaminoceptive medium spiny neurons in the striatum by manually identifying candidate regulatory regions or employing the OnTarget webserver. We then empirically tested the designs in rA...

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Literature Corpus work: 3c60d4ca-f2b3-5b45-974f-072b3176bc0a
DOI: 10.21203/rs.3.rs-5086329/v1

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New MiniPromoter Ple389 (ADORA2A) Drives Selective Expression in Medium Spiny Neurons in Mice and Non-human PrimatesDOI 10.21203/rs.3.rs-5086329/v1Read

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