Coordination of bladder peripheral clock and diurnal micturition pattern by glucocorticoids

Abstract excerpt

Peripheral clocks function to regulate each organ and are synchronized though various molecular and behavioral signals. However, signals that entrain the bladder clock remain elusive. Here, we show that glucocorticoids are a key cue for the bladder clock in vitro and in vivo . A p Bmal1 -dLuc human urothelial cell-line showed significant shifts in gene expression after cortisol treatment. In vivo , rhythmic bladde...

Topics

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• Adrenal Cortex
• Adrenal Cortex Hormones
• ARNTL Transcription Factors
• Cholesterol Side-Chain Cleavage Enzyme
• Circadian Rhythm
• Corticosterone
• Glucocorticoids
• Physical Conditioning, Animal

Identifiers and source

Literature Corpus work

3bd79cb9-83a2-55e5-8a0c-6841ba259327

DOI

10.21203/rs.3.rs-1780404/v1