Article
Resetting of circadian time in peripheral tissues by glucocorticoid signaling.
Science (New York, N.Y.) - 29 Sept 2000
Balsalobre A, Brown S A, Marcacci L, Tronche F, Kellendonk C, Reichardt H M, Schütz G, Schibler U
Abstract excerpt
In mammals, circadian oscillators reside not only in the suprachiasmatic nucleus of the brain, which harbors the central pacemaker, but also in most peripheral tissues. Here, we show that the glucocorticoid hormone analog dexamethasone induces circadian gene expression in cultured rat-1 fibroblasts and transiently changes the phase of circadian gene expression in liver, kidney, and heart. However, dexamethasone...
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