Article

Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis

2024-03-27

Abstract excerpt

Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal progenitors that can contribute to muscle tissue homeostasis and regeneration, as well as postnatal maturation and lifelong maintenance of the neuromuscular system. Recently, traumatic injury to the peripheral nerve was shown to activate FAPs, suggesting that FAPs can respond to nerve injury. However, questions of how FAPs can sense the anatomical...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3bb524c7-f571-55dc-a9d4-49b7c1e38dc2
DOI: 10.1101/2024.03.25.586563

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axisDOI 10.1101/2024.03.25.586563Read

Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and diseaseSemantic proximity Read

Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis.Semantic proximity Read

Integrin-driven Axon Regeneration in the Spinal Cord Activates a Distinctive CNS Regeneration ProgramSemantic proximity Read

Characterising cellular and molecular features of human peripheral nerve degenerationSemantic proximity Read

Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populationsSemantic proximity Read

New Frontiers in Peripheral Nerve Regeneration: Concerns and RemediesSemantic proximity Read

Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within musclesSemantic proximity Read

Spinal cord injury reprograms muscle fibro-adipogenic progenitors to form heterotopic bones within musclesSemantic proximity Read

Atf3 mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury.Semantic proximity Read

Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and RegenerationSemantic proximity Read

Molecular and cellular processes of deafferentation after plexus injury in human dorsal root gangliaSemantic proximity Read

Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve RepairSemantic proximity Read