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Hypoxic conditions promote a proliferative, poorly differentiated, and pro-secretory phenotype in COPD lung tissue progenitor cells in vitro

2022-03-22

Abstract excerpt

Chronic obstructive pulmonary disease patients experience variable symptoms dependent on the presence of an emphysematous versus a chronic bronchitis phenotype. Both presentations can be associated with lung tissue and systemic hypoxia, at its most severe leading to Cor pulmonale. Despite this, minimal attention has been given to the effects of hypoxia at the cellular disease level. We isolated and cultured progen...

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Literature Corpus work
3bb25c3c-39c1-501d-939f-8fbbaa110047
DOI
10.1101/2022.03.22.484879
Open publication

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Hypoxic conditions promote a proliferative, poorly differentiated, and pro-secretory phenotype in COPD lung tissue progenitor cells in vitroDOI 10.1101/2022.03.22.484879
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