Article

A robust, sensitive phylogenetic method enables gene-level metagenomic analyses

2026-07-15

Abstract excerpt

A key goal in the microbiome field is to move from taxonomic associations towards mechanistic hypotheses about microbial gene function. However, most methods for linking microbiome changes to specific genes are biased towards finding marker genes, with weak evidence for functional relevance. Phylogenetic regression can address this issue and has been previously applied to changes in microbial prevalence, but many...

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Literature Corpus work: 3ba991f1-3060-5177-b41b-e071bec66a54
DOI: 10.64898/2026.07.15.738679

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