Article

A realistic benchmark for the identification of differentially abundant taxa in (confounded) human microbiome studies

2022-05-10

Abstract excerpt

<h4>Background</h4> In microbiome disease association studies, it is a fundamental task to test which microbes differ in their abundance between groups. Yet, consensus on suitable or optimal statistical methods for differential abundance (DA) testing is lacking, and it remains unexplored how these cope with confounding. Previous DA benchmarks relying on simulated datasets did not quantitatively evaluate the simil...

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Literature Corpus work: 5867aaf0-f93b-5491-bc21-61cdc331ee90
DOI: 10.1101/2022.05.09.491139

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