Article

MUSiCC: A marker genes based framework for metagenomic normalization and accurate profiling of gene abundances in the microbiome

2014-09-19

Abstract excerpt

Functional metagenomic analyses commonly involve a normalization step, where measured levels of genes or pathways are converted into relative abundances. Here, we demonstrate that this normalization scheme introduces marked biases both across and within human microbiome samples and systematically identify various sample-and gene-specific properties that contribute to these biases. We introduce an alternative norma...

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Literature Corpus work: 157e9102-d032-5f5d-b63f-0180f1a244a7
DOI: 10.1101/009407

Open publication

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