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Super-resolved imaging of mRNA ultrastructure in cells

2026-01-23

Abstract excerpt

Messenger RNA (mRNA) is a central polymer of gene expression, whose ultrastructure and defining regulatory rules remain unclear. To visualize the ultrastructure of mRNA, we here develop Combi-PAINT, a powerful and generalizable method for combinatorial super-resolved DNA-PAINT multiplexing, which we combine with high-efficiency RNA labelling and MINFLUX microscopy. This approach enables the nanometer-precision tra...

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Literature Corpus work
3b98bbc8-a0e7-5116-b1e7-c899534c17c6
DOI
10.64898/2026.01.23.701081
Open publication

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Super-resolved imaging of mRNA ultrastructure in cellsDOI 10.64898/2026.01.23.701081
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