Article

A bioinorganic view on the potential chemical space of hydroxyphenylpyruvate dioxygenase- like (HPDL) enzymes

2025-10-01

Abstract excerpt

<title>Abstract</title> <p>Genetic analyses have identified biallelic variants in the <italic>4-hydroxyphenylpyruvate dioxygenase-like</italic> (<italic>HPDL</italic>) gene as the cause of a neurodegenerative disease that resembles the primary coenzyme Q10 (CoQ10) deficiency syndromes. HPDL is structurally similar to the well-studied 4-hydroxyphenyl pyruvate dioxygenase (HPPD), an iron(II)/α-ketoacid dependent en...

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Literature Corpus work: 3b35a325-7de2-552c-8815-47a8da7e90ec
DOI: 10.21203/rs.3.rs-7694155/v1

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