Article
4-hydroxyphenylpyruvate dioxygenase catalysis: identification of catalytic residues and production of a hydroxylated intermediate shared with a structurally unrelated enzyme.
The Journal of biological chemistry - 22 Jul 2011
Raspail Corinne, Graindorge Matthieu, Moreau Yohann, Crouzy Serge, Lefèbvre Bertrand, Robin Adeline Y, Dumas Renaud, Matringe Michel
Abstract excerpt
4-Hydroxyphenylpyruvate dioxygenase (HPPD) catalyzes the conversion of 4-hydroxyphenylpyruvate (HPP) into homogentisate. HPPD is the molecular target of very effective synthetic herbicides. HPPD inhibitors may also be useful in treating life-threatening tyrosinemia type I and are currently in trials for treatment of Parkinson disease. The reaction mechanism of this key enzyme in both plants and animals has not...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.