Article

HALPred-B: Host-Aware Linear B-Cell Epitope Prediction: Challenges, Limitations, and Variability Across Species

2026-06-26

Abstract excerpt

Predicting linear B-cell epitopes is a basic immunoinformatics task that has a direct impact on vaccine design and antibody engineering. Recent advances in machine learning have improved predictive performance, but most existing approaches are trained on aggregated datasets and assume that antigenic patterns are conserved across host organisms. This assumption ignores the immunological variability depending on the...

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Literature Corpus work: f498dce6-019f-55e5-bfed-2641ae5c57e7
DOI: 10.64898/2026.06.22.733770

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