Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigating the shared genetic links between hypothyroidism and psychiatric disorders: a large-scale genomewide cross-trait analysis.

Journal of affective disorders - 15 Jan 2025

Chen Yanjing, Zhang Zhiyi, Chen Yongyi, Liu Ping, Yi Sijie, Fan Chunhua, Zhao Wei, Liu Jun

Abstract excerpt

BACKGROUND: Associations between thyroid diseases and psychiatric disorders have been mainly described before. However, the genetic mechanism behind hypothyroidism and psychiatric disorders remains unexplained. METHODS: We examined the genetic architecture of hypothyroidism and 8 psychiatric disorders. Firstly, the global and local genetic relationship between the paired traits was explored. Secondly, cross-trait...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Associations and Epidemiology
Share to Genetic Pleiotropy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Hypothyroidism

Share to Mental Disorders

Share to Polymorphism, Single Nucleotide

Share to Thyroid Disorders and Treatments

Source

Identifiers

PMID: 39353512
DOI: 10.1016/j.jad.2024.08.202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating the shared genetic links between hypothyroidism and psychiatric disorders: a large-scale genomewide cross-trait analysis.PMID 39353512Read ↗

Shared genetic links between hypothyroidism and psychiatric disorders: evidence from a comprehensive genetic analysis.Semantic proximity Read ↗

Shared genetic architecture between hypothyroidism and rheumatoid arthritis: A large-scale cross-trait analysis.Semantic proximity Read ↗

Dissecting shared genetic architecture between hypothyroidism and immune-related diseasesSemantic proximity Read ↗

Shared Genetic Basis, Biological Function and Causal Relationship Between Sleep Traits and Hypothyroidism: Evidence from a Comprehensive Genetic Analysis.Semantic proximity Read ↗

Genome-wide association study and polygenic risk prediction of hypothyroidismSemantic proximity Read ↗

Novel associations for hypothyroidism include known autoimmune risk loci.Semantic proximity Read ↗

Shared genetic architecture and pathways linking major depressive disorder and autoimmune thyroid disease: insights from common and rare variants.Semantic proximity Read ↗

The Etiology of Hypothyroidism Is Revealed by Alternative Genetics Association Study MethodologiesSemantic proximity Read ↗

Functional Insights into Hypothyroidism Etiology through Complementary Genetic Association MethodsSemantic proximity Read ↗

Integrative multi-omics analyses identify key genes and elucidate bidirectional regulatory mechanisms in thyroid dysfunction.Semantic proximity Read ↗

Genetic correlation and causal relationships between autoimmune thyroid disease and major depressive disorders.Semantic proximity Read ↗

Interactions between Polygenetic Variants and Lifestyle Factors in Hypothyroidism: A Hospital-Based Cohort StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.