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Article

Investigating the shared genetic links between hypothyroidism and psychiatric disorders: a large-scale genomewide cross-trait analysis.

Journal of affective disorders - 15 Jan 2025

Chen Yanjing, Zhang Zhiyi, Chen Yongyi, Liu Ping, Yi Sijie, Fan Chunhua, Zhao Wei, Liu Jun

Abstract excerpt

BACKGROUND: Associations between thyroid diseases and psychiatric disorders have been mainly described before. However, the genetic mechanism behind hypothyroidism and psychiatric disorders remains unexplained. METHODS: We examined the genetic architecture of hypothyroidism and 8 psychiatric disorders. Firstly, the global and local genetic relationship between the paired traits was explored. Secondly, cross-trait...

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Genetic Associations and Epidemiology
Genetic Pleiotropy
Genetic Predisposition to Disease
Genome-Wide Association Study
Hypothyroidism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mental Disorders

Polymorphism, Single Nucleotide

Thyroid Disorders and Treatments

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PMID: 39353512
DOI: 10.1016/j.jad.2024.08.202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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