Article

Learning the Therapeutic Targets of Acute Myeloid Leukemia through Multiscale Human Interactome Network and Community Analysis

2024-09-03

Abstract excerpt

<title>Abstract</title> <p>Acute myeloid leukemia (AML) is caused by proliferation of mutated myeloid progenitor cells. The standard chemotherapy regimen does not efficiently cause remission as there is a high relapse rate. Resistance acquired by leukemic stem cells is suggested to be one of the root causes for relapse. Therefore, there is an urgency to develop new drugs for therapy. Repurposing approved drugs fo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a5d13d9-1095-5c9f-a06a-0d891ba58b24
DOI: 10.21203/rs.3.rs-4803409/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Learning the Therapeutic Targets of Acute Myeloid Leukemia through Multiscale Human Interactome Network and Community AnalysisDOI 10.21203/rs.3.rs-4803409/v1Read

Molecular Systems Architecture of Interactome in the Acute Myeloid Leukemia MicroenvironmentSemantic proximity Read

Network-based analysis with primary cells reveals drug response landscape of acute myeloid leukemia.Semantic proximity Read

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemiaSemantic proximity Read

High Throughput Bioinformatics-based Prediction of the targets for BushenjieduDecoction in preventing relapse of acute leukemiaSemantic proximity Read

The Central Importance of Hub Proteins in a Disease-Gene Network Model: A New Paradigm of Chronic Myeloid Leukemia Disease StudySemantic proximity Read

Genetic Chinese Medicine Network Pharmacology Research, Quercetin Improves Drug Resistance in Acute Myeloid Leukemia by Targeting CXCL10Semantic proximity Read

Network Pharmacology-Based Strategy for Predicting Therapy Targets of Tripterygium wilfordii on Acute Myeloid LeukemiaSemantic proximity Read

Construction of a solid Cox model for AML patients based on multiomics bioinformatic analysisSemantic proximity Read

A scalable method for molecular network reconstruction identifies properties of targets and mutations in acute myeloid leukemia.Semantic proximity Read

Identification of prognostic genes in the acute myeloid leukemia microenvironmentSemantic proximity Read

Network Pharmacology-Based Strategy for Predicting Therapy Targets of Tripterygium wilfordii on Acute Myeloid LeukemiaSemantic proximity Read