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Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver

28 Nov 2016

Abstract excerpt

1. The aim of the present study was to evaluate the usefulness of chimeric mice with humanised liver (PXB mice) for the prediction of clearance (CLt) and volume of distribution at steady state (Vdss), in comparison with monkeys, which have been reported as a reliable model for human pharmacokinetics (PK) prediction, and with rats, as a conventional PK model.2. CLt and Vdss values in PXB mice, monkeys and rats...

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PMID: 27892765
DOI: 10.1080/00498254.2016.1265160

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