Article

A brief exposure to rotenone alters microtubule dynamics resulting in aberrant elongation of primary cilia with impaired function

2025-12-29

Abstract excerpt

Rotenone, an environmental toxin, is widely used to model Parkinson’s disease owing to its well-studied effect to inhibit mitochondrial complex I function and to increase Reactive Oxygen Species (ROS), thereby leading to dopaminergic neuron degeneration. Less appreciated is its impact on microtubules (MT), except for suggesting that it promotes microtubule depolymerization, raising the question of whether rotenone...

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Literature Corpus work: 3a506c47-5788-5bf0-b7f0-c1afb6ce068a
DOI: 10.64898/2025.12.29.696880

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