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Article

Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle.

The Journal of general physiology - 1 Nov 2006

Csanády László, Nairn Angus C, Gadsby David C

Abstract excerpt

CFTR is the only ABC (ATP-binding cassette) ATPase known to be an ion channel. Studies of CFTR channel function, feasible with single-molecule resolution, therefore provide a unique glimpse of ABC transporter mechanism. CFTR channel opening and closing (after regulatory-domain phosphorylation) follows an irreversible cycle, driven by ATP binding/hydrolysis at the nucleotide-binding domains (NBD1, NBD2). Recent...

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Identifiers

PMID: 17043148
DOI: 10.1085/jgp.200609558
PMCID: PMC2151586

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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