Utilizing Genomics to Identify Novel Immunotherapeutic Targets in Multiple Myeloma High-Risk Subgroups

Abstract excerpt

Immunotherapy is now standard of care for multiple myeloma, where the most common targets are B cell maturation antigen, CD38, and G protein-coupled receptor class C group 5 member D but strategies to identify additional targets are needed. We have utilized two large datasets of genomic data and integrated them with existing databases to identify expressed cell surface targets in myeloma patients. Importantly, we...

Topics

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• Gene Expression Profiling
• Genome-Wide Association Study
• Genomics
• Multiple Myeloma
• Polymerase Chain Reaction
• Polymorphism, Single Nucleotide
• Prognosis
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

3a163556-4fa8-5e9e-aa3f-308c35aea25a

DOI

10.1101/2025.01.29.635544