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Multi-omics analysis of multiple myeloma patients with differential response to first-line treatment.

Clinical and experimental medicine - 1 Nov 2023

Zheng Bo, Yi Ke, Zhang Yajun, Pang Tongfang, Zhou Jieyi, He Jie, Lan Hongyan, Xian Hongming, Li Rong

Abstract excerpt

The genome backgrounds of multiple myeloma (MM) would affect the efficacy of specific treatment. However, the mutational and transcriptional landscapes in MM patients with differential response to first-line treatment remains unclear. We collected paired whole-exome sequencing (WES) and transcriptomic data of over 200 MM cases from MMRF-COMPASS project. R package, maftools was applied to analyze the somatic...

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PMID: 37515690
DOI: 10.1007/s10238-023-01148-4

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