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The distinct role of ALDH1A1 and ALDH1A3 in the regulation of prostate cancer metastases

2021-05-10

Abstract excerpt

Cancer stem cells (CSC) are characterized by high self-renewal capacity, tumor-initiating potential, and therapy resistance. Aldehyde dehydrogenase (ALDH)+ cell population serves as an indicator of prostate CSCs with increased therapy resistance, enhanced DNA double-strand break repair, and activated epithelial-mesenchymal transition (EMT) and migration. Numerous ALDH genes contribute to ALDH enzymatic activity; h...

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Identifiers and source

Literature Corpus work
398485cd-7e19-55ca-830c-bf43d3b875e5
DOI
10.1101/2021.05.08.443223
Open publication

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The distinct role of ALDH1A1 and ALDH1A3 in the regulation of prostate cancer metastasesDOI 10.1101/2021.05.08.443223
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