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The aldehyde dehydrogenase enzyme 7A1 is functionally involved in prostate cancer bone metastasis

6 Jun 2011

Abstract excerpt

High aldehyde dehydrogenase (ALDH) activity can be used to identify tumor-initiating and metastasis-initiating cells in various human carcinomas, including prostate cancer. To date, the functional importance of ALDH enzymes in prostate carcinogenesis, progression and metastasis has remained elusive. Previously we identified strong expression of ALDH7A1 in human prostate cancer cell lines, primary tumors and...

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PMID: 21647815
DOI: 10.1007/s10585-011-9395-7

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