Article

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia

2019-05-07

Abstract excerpt

Juvenile Myelomonocytic Leukemia (JMML) is a poor prognosis childhood leukemia usually caused by germline or somatic RAS-activating mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-cell RNA-sequencing reveal marked heterogeneity of JMML hematopoietic stem/progenitor cells (HSPCs), including an aberrant Lin-CD34+CD38-CD90+CD45RA...

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Literature Corpus work: 3965b8d7-91ab-5213-8f03-466e509a6cc0
DOI: 10.1101/628479

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