Article
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.
The Journal of experimental medicine - 1 Feb 2021
Louka Eleni, Povinelli Benjamin, Rodriguez-Meira Alba, Buck Gemma, Wen Wei Xiong, Wang Guanlin, Sousos Nikolaos, Ashley Neil, Hamblin Angela, Booth Christopher A G, Roy Anindita, Elliott Natalina, Iskander Deena, de la Fuente Josu, Fordham Nicholas, O'Byrne Sorcha, Inglott Sarah, Norfo Ruggiero, Salio Mariolina, Thongjuea Supat, Rao Anupama, Roberts Irene, Mead Adam J
Abstract excerpt
Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-cell RNA sequencing reveal marked heterogeneity of JMML hematopoietic stem/progenitor cells (HSPCs), including an aberrant Lin-CD34+CD38-CD90+CD45RA+ population....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.