Phenotypic screening for new heart failure therapeutics: scalable animal modeling in zebrafish.

Abstract excerpt

INTRODUCTION: Congestive heart failure (CHF) is a complex multi-organ syndrome representative of many chronic 'diseases,' and as such it has proven resistant to traditional cell-based drug discovery cannot readily be captured the relevant systemic biology. In vivo drug discovery screens offer unique opportunities to identify the initial dysfunction which ultimately drives heart failure (HF) and novel pathways...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Disease Models, Animal
• Share to Drug Discovery
• Share to Drug Evaluation, Preclinical