Integrated multi-omics data analysis identifies a novel genetics-risk gene of<i>IRF4</i>associated with prognosis of oral cavity cancer

Abstract excerpt

<h4>Background</h4> Oral cavity cancer (OCC) is one of the most common carcinoma diseases. Recent genome-wide association studies (GWAS) have reported numerous genetic variants associated with OCC susceptibility. However, the regulatory mechanisms of these genetic variants underlying OCC remain largely unclear. <h4>Objective</h4> This study aimed to identify OCC-related genetics risk genes contributing to the prog...

Topics

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• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• Gene Regulatory Networks
• Mendelian Randomization Analysis
• Mouth Neoplasms
• Multiomics
• Protein Interaction Maps
• Quantitative Trait Loci

Identifiers and source

Literature Corpus work

9fa29c7c-6136-5372-8c6c-93fa8c693566

DOI

10.1101/2021.11.17.21266500