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Article

Single-cell transcriptomic profiling combined with Mendelian randomization illuminates molecular drivers of bladder cancer.

Molecular genetics and genomics : MGG - 4 Mar 2026

He Junrui, Jiang Zhuoying, Peng Shan, Peng Lijuan, Xia Zhongyou, Ma Ting, Tan Xiaojun, Long Qiongxian, Wu Ji

Abstract excerpt

Bladder cancer exhibits marked cellular heterogeneity, which complicates the identification of molecular drivers with both functional and genetic relevance. The link between genetic susceptibility and transcriptional activity in tumorigenesis remains incompletely understood. Single-cell transcriptomes of bladder carcinoma and adjacent normal tissues were processed using Seurat and Harmony for data normalization,...

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Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41779063
DOI: 10.1007/s00438-026-02371-w
PMCID: PMC12960442

Genes

ARHGEF18
YPEL5
CCK
ISG20
NCF1
RPL13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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