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Article

BRD4: New hope in the battle against glioblastoma

13 Apr 2023

Abstract excerpt

The BET family proteins, comprising BRD2, BRD3 and BRD4, represent epigenetic readers of acetylated histone marks that play pleiotropic roles in the tumorigenesis and growth of multiple human malignancies, including glioblastoma (GBM). A growing body of investigation has proven BET proteins as valuable therapeutic targets for cancer treatment. Recently, several BRD4 inhibitors and degraders have been reported to...

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PMID: 37061146
DOI: 10.1016/j.phrs.2023.106767

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