Meta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene.

doi:10.1371/journal.pgen.1005914

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Meta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene.

PLoS genetics - 1 Mar 2016

Ludwig Kerstin U, Ahmed Syeda Tasnim, Böhmer Anne C, Sangani Nasim Bahram, Varghese Sheryil, Klamt Johanna, Schuenke Hannah, Gültepe Pinar, Hofmann Andrea, Rubini Michele, Aldhorae Khalid Ahmed, Steegers-Theunissen Regine P, Rojas-Martinez Augusto, Reiter Rudolf, Borck Guntram, Knapp Michael, Nakatomi Mitsushiro, Graf Daniel, Mangold Elisabeth, Peters Heiko

Abstract excerpt

Nonsyndromic orofacial clefts are common birth defects with multifactorial etiology. The most common type is cleft lip, which occurs with or without cleft palate (nsCLP and nsCLO, respectively). Although genetic components play an important role in nsCLP, the genetic factors that predispose to palate involvement are largely unknown. In this study, we carried out a meta-analysis on genetic and clinical data from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 15

Share to Cleft Lip

Share to Cleft Palate

Share to Genome-Wide Association Study

Share to Intercellular Signaling Peptides and Proteins

Share to Mice

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 26968009
DOI: 10.1371/journal.pgen.1005914
PMCID: PMC4788144

Genes

GREM1
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Meta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene.PMID 26968009Read ↗

Nonsyndromic cleft lip with or without cleft palate: Increased burden of rare variants within Gremlin-1, a component of the bone morphogenetic protein 4 pathway.Semantic proximity Read ↗

Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.Semantic proximity Read ↗

Association of Genetic Polymorphisms of GREM1 Gene with Susceptibility to Non-Syndromic Cleft Lip with or without Cleft Palate in an Iranian Population.Semantic proximity Read ↗

Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity.Semantic proximity Read ↗

Genome-wide Analyses Identify a Novel Risk Locus for Nonsyndromic Cleft Palate.Semantic proximity Read ↗

Exploration of Genetic Variants of Non-syndromic Cleft Lip with or without Palate and Underlying Mechanisms.Semantic proximity Read ↗

Advances in genetic mechanisms and precision medicine research for cleft lip and palate.Semantic proximity Read ↗

Progress toward discerning the genetics of cleft lip.Semantic proximity Read ↗

Association between a single-nucleotide polymorphism in the GREM1 gene and non-syndromic orofacial cleft in the Chinese population.Semantic proximity Read ↗

Unraveling human cleft lip and palate research.Semantic proximity Read ↗

Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiologySemantic proximity Read ↗

Prioritization of non-coding elements involved in non-syndromic cleft lip with/without cleft palate through genome-wide analysis of de novo mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.