Article

Dopaminergic Modulation of Working Memory and Cognitive Flexibility in a Zebrafish Model of Aging-Related Cognitive Decline

2020-06-06

Abstract excerpt

Healthy aging is associated with a decline in memory and executive function, which have both been linked with aberrant dopaminergic signalling. We examined the relationship between cognitive performance and dopamine function of young and aging zebrafish ( Danio rerio ). We revealed age-related decreases in working memory and cognitive flexibility in the Free-Movement Pattern (FMP) Y-maze. An increase in drd5 gen...

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Literature Corpus work: 388e24d7-b04c-5359-89a0-50bfc4eb5087
DOI: 10.1101/2020.06.05.136077

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