Article

Chemokine Signaling Shapes Hepatic Lipid Homeostasis through the CXCL12/CXCR4/CXCR7 Axis

2025-12-06

Abstract excerpt

The CXCL12/CXCR4/CXCR7 signaling axis, long recognized for its roles in cancer, fibrosis, and tissue repair, is emerging as a broader regulator of tissue homeostasis. Here, we uncover a previously unappreciated function of this pathway in regulating hepatic metabolism. We show that Cxcl12 , Cxcr4 , and Ackr3 (encoding CXCR7) are dynamically regulated during the fasting-refeeding transition and become dysregulat...

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Literature Corpus work: 386a0c00-13cf-50bb-bbd3-165caa603d67
DOI: 10.64898/2025.12.03.692068

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