Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

30 Nov 2018

Abstract excerpt

Abstract Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men, but the molecular mechanism remains obscure. Here, we show that an androgen receptor (AR)-driven oncogene, cell cycle-related kinase (CCRK), collaborates with obesity-induced pro-inflammatory signaling to promote non-alcoholic steatohepatitis (NASH)-related hepatocarcinogenesis. Lentivirus-mediated Ccrk ablation in liver of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Pancreatic function and diabetes
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30523261
DOI: 10.1038/s41467-018-07402-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinomaPMID 30523261Read ↗

Investigating the causal association between obesity and risk of hepatocellular carcinoma and underlying mechanismsSemantic proximity Read ↗

Occurrence of Biased mTOR Signaling in Hepatocellular CarcinomaSemantic proximity Read ↗

Cell cycle–related kinase is a direct androgen receptor–regulated gene that drives β-catenin/T cell factor–dependent hepatocarcinogenesisSemantic proximity Read ↗

STAT3 restricts prostate cancer metastasis and antiandrogen resistance by controlling LKB1/CREB signaling pathwaySemantic proximity Read ↗

Bi-steric mTORC1-selective Inhibitors activate 4EBP1 reversing MYC-induced tumorigenesis and synergize with immunotherapySemantic proximity Read ↗

Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosisSemantic proximity Read ↗

Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPARα and PCK1 action in hepatocytesSemantic proximity Read ↗

Oncogene-dependent addiction to carbohydrate-responsive element binding protein in hepatocellular carcinomaSemantic proximity Read ↗

Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in MiceSemantic proximity Read ↗

RORγ is a context-specific master regulator of cholesterol biosynthesis and an emerging therapeutic target in cancer and autoimmune diseasesSemantic proximity Read ↗

Adipocyte JAK2 mediates aging-associated metabolic liver disease and progression to hepatocellular carcinomaSemantic proximity Read ↗

Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.