Article

MUC16-dependent Renal Vascular Adhesion of Candida Promotes Tissue Invasion and Predicts Clinical Outcome in Candidemia

2026-03-04

Abstract excerpt

<title>Abstract</title> <p>Bloodstream infection with Candida species is associated with high mortality, yet the molecular basis of vascular adhesion and invasion remains unclear. We identify the endothelial surface mucin MUC16 as a key host factor enabling fungal vascular adherence. The MUC16 SEA domain directly engages the Candida adhesin Als3p and endothelial N-cadherin to form a ternary complex that promotes...

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Literature Corpus work: 3849fed1-1893-53c8-9905-d96b811d8ff0
DOI: 10.21203/rs.3.rs-8810991/v1

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