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Circular RNA aptamers ameliorate AD-relevant phenotypes by targeting PKR

2024-03-27

Abstract excerpt

Here, we delineated the remarkably elevated neuroinflammation accompanied by progressive activation of double-stranded RNA (dsRNA)-activated Protein Kinase R (PKR) and PKR-related dsRNA pathways in hippocampus of 5×FAD mice upon Alzheimer’s disease (AD) progression. AAV-delivery of circular RNAs possessing short-imperfect duplex regions (ds-cRNAs) to neurons and microglia effectively dampened excessive PKR activit...

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Literature Corpus work
382748b7-bf66-5fa5-87b9-07b8bbbba2a5
DOI
10.1101/2024.03.27.583257
Open publication

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Circular RNA aptamers ameliorate AD-relevant phenotypes by targeting PKRDOI 10.1101/2024.03.27.583257
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