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Article

Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models.

Nature biotechnology - 1 Mar 2026

Feng Xin, Jiang Bo-Wen, Zhai Si-Nan, Liu Chu-Xiao, Wu Hao, Zhu Bang-Qi, Wei Meng-Yuan, Wei Jia, Yang Li, Chen Ling-Ling

Abstract excerpt

Alzheimer disease (AD) therapy may benefit from optimized approaches to inhibit neuroinflammation. Small-molecule inhibitors of the proinflammatory molecule double-stranded RNA (dsRNA)-activated protein kinase R (PKR) have efficacy in AD models but their utility is compromised by adverse side effects. Here, we target PKR in two mouse models of AD using circular RNAs containing short double-stranded regions...

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PMID: 40164764
DOI: 10.1038/s41587-025-02624-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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