Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance.

doi:10.1371/journal.pgen.1008551

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Article

Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance.

PLoS genetics - 1 Dec 2019

de Castro Patrícia Alves, Colabardini Ana Cristina, Manfiolli Adriana Oliveira, Chiaratto Jéssica, Silva Lilian Pereira, Mattos Eliciane Cevolani, Palmisano Giuseppe, Almeida Fausto, Persinoti Gabriela Felix, Ries Laure Nicolas Annick, Mellado Laura, Rocha Marina Campos, Bromley Michael, Silva Roberto Nascimento, de Souza Gabriel Scalini, Loures Flávio Vieira, Malavazi Iran, Brown Neil Andrew, Goldman Gustavo H

Abstract excerpt

Aspergillus fumigatus causes invasive aspergillosis, the most common life-threatening fungal disease of immuno-compromised humans. The treatment of disseminated infections with antifungal drugs, including echinocandin cell wall biosynthesis inhibitors, is increasingly challenging due to the rise of drug-resistant pathogens. The fungal calcium responsive calcineurin-CrzA pathway influences cell morphology, cell...

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PMID: 31887136
DOI: 10.1371/journal.pgen.1008551
PMCID: PMC6948819

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