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Article

Capsid-CPSF6 interaction: Master regulator of nuclear HIV-1 positioning and integration

1 Jun 2019

Abstract excerpt

HIV-1 integration favors active chromatin, which is primarily mediated through interactions between the viral capsid and integrase proteins with host factors cleavage and polyadenylation specificity factor 6 (CPSF6) and lens epithelium-derived growth factor/p75, respectively. Previously published image-based studies had suggested that HIV-1 prefers to integrate into chromatin that associates spatially with the...

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PMID: 31448372
DOI: 10.36069/jols/20190604

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