Article
KLK3 germline mutation I179T complements DNA repair genes for predicting prostate cancer progression.
Prostate cancer and prostatic diseases - 1 Apr 2022
Xu Jianfeng, Shi Zhuqing, Wei Jun, Na Rong, Resurreccion W Kyle, Wang Chi-Hsiung, Sample Chris, Han Misop, Zheng S Lilly, Cooney Kathleen A, Helfand Brian T, Isaacs William B
Abstract excerpt
BACKGROUND: Germline mutations in DNA repair genes and KLK3 have been associated with adverse prostate cancer (PCa) outcomes in separate studies but never jointly. The objective of this study is to simultaneously assess these two types of germline mutations. METHODS: Germline rare pathogenic mutations (RPMs) in 9 commonly tested DNA repair genes and KLK3 variants were tested for their associations with PCa...
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